Hoof Wall Separation Disease (HWSD) is characterized by separation and breakage of the dorsal hoof wall extending up from the sole. Symptoms of affected ponies begin at less than 6 months of age, and often lead to development of chronic laminitis.

Hydrocephalus (HDC) is an abnormal build up of cerebral spinal fluid around the brain. It is believed that a narrowed passage within the brain prevents normal fluid absorption, leading to an obvious external cranial distension. Affected foals are often stillborn and are associated with dystocia in the dams.

Hyperkalemic Periodic Paralysis (HYPP) is caused by defects in sodium channels within the muscle, which can lead to paralysis, collapse and sudden death. Affected animals experience episodes of muscular weakness or tremors.

Impaired Acrosomal Reaction Subfertility (IAR) causes sub- or infertility in males. In normal fertilization, the the head of a sperm binds to the egg and releases the contents of a structure known as the acrosome. However, some males with IAR are unable to properly carry out this process.

Junctional Epidermolysis Bullosa (JEB), also known as red foot disease or hairless foal syndrome, results in the inability to produce the proteins needed to keep the skin on the body. Affected foals exhibit symptoms within days of birth, including blisters at the pressure points, detatchment of the hooves, and oral ulcers. As there is no treatment, affected foals are humanely euthanized.

Kissing Spines Susceptibility (KSS) evaluates a horses genetic risk for developing Kissing Spines. Horses diagnosed with Kissing Spines will have two or more dorsal spinous processes that are too close together, touch, or even overlap. This bone-on-bone grinding causes varying degrees of pain, and thus decreased mobility.

Lavender foal syndrome (LFS), also known as coat color dilution lethal, is a neurological dysfunction in newborn foals. Symptoms are apparent at birth and include seizures, severe hyper-extension of limbs, neck and back, stiff paddling leg movements, involuntary eye movement and inability to stand or sit upright. The coat usually has a dilute color that ranges in shade from silver to a pale lavender/pink. As there is no treatment, affected foals are humanely euthanized.